SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat exactly the same ailment in several people. This is not pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall go through the various factors that decide selecting a specific drug.
Safety: These sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug regardless of whether they have certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicationdirectory.com might be safe in short-term treatment, but how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals answer produce a different chemical, which has an effect that could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually generate the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two drugs are more intense.
Tolerability: A medicine might be effective although not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability should be looked at. Efficacy: A medicine is just not equally effective in all patients. By way of example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are lots of that don’t, who therefore should be prescribed some other anti-depressant. The interest rate of onset of therapeutic action is a vital factor to be regarded as too.
Cost: Cost does not necessarily mean the cost of purchase of a certain medicine alone. It must also cover the cost of management of a complication that could arise from utilizing some other drug. Example: In a one who insists on taking alcohol yet should be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another group of anti-depressants (such as tricyclics) may cause a fresh overuse injury in such patients, which would require a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than a cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. If there is an alternative between a shot and oral administration, the latter is preferred in the event the efficacy of the two modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to decide simple treatment.
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