SINCE World war 2, medical science has progressed to a stage where competitive medications are around to treat the same ailment in different people. It’s not nearly brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall go through the various factors that decide your selection of a specific drug.
Safety: The following sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug regardless of whether it has certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possible side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, so how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals answer create a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same effect on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two drugs are more serious.
Tolerability: A medicine might be effective and not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medicine just isn’t equally good at all patients. For instance, some patients with depression or anxiety attacks experience rest from escitalopram, but there are many who don’t, who therefore need to be prescribed a different anti-depressant. The pace of start of therapeutic action is a the answer to be regarded as too.
Cost: Cost does not necessarily mean the cost of purchase of a certain medicine alone. It will also cover the cost of treating a complication that may arise while using a different drug. Example: In a one who insists on taking alcohol but must be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another band of anti-depressants (for example tricyclics) might cause a fresh condition in such patients, which could demand a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. When there is a selection between an injection and oral administration, rogues is preferred in the event the efficacy of the two modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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