SINCE Wwii, medical science has progressed with a stage where competitive medications are around to treat the same ailment in numerous people. This isn’t pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall go through the various factors that decide the selection of a certain drug.
Safety: The following sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even though it’s got certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the potential side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and many chemicals respond to produce a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually make the same impact on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the drugs are more serious.
Tolerability: A drug could possibly be effective but not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability must be taken into account. Efficacy: A drug is just not equally efficient at all patients. By way of example, some patients with depression or anxiety attacks experience relief from escitalopram, but there are many who don’t, who therefore must be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a crucial key to be looked at too.
Cost: Cost does not mean the price of purchase of a specific medicine alone. It ought to also cover the price of treating a complication that may arise by using an alternative drug. Example: In the individual who insists on taking alcohol nevertheless has to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (including tricyclics) could cause a fresh overuse injury in such patients, which may need a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram instead of a cheaper tricyclic such patients.
Simple treatment: The simplest mode of administration is preferred. When there is a selection between an injection and oral administration, rogues is preferred if the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to choose simple treatment.
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