SINCE Wwii, medical science has progressed into a stage where competitive medications are for sale to treat precisely the same ailment in several people. This is not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall consider the various factors that decide selecting a selected drug.
Safety: The subsequent sub-criteria should be considered underneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even if it’s got certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: medication may be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals react to produce a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same effect on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the medicine is more intense.
Tolerability: A drug may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug isn’t equally efficient at all patients. By way of example, some patients with depression or panic disorders experience reduced escitalopram, but there are numerous that don’t, who therefore need to be prescribed another anti-depressant. The pace of start of therapeutic action is a vital factor to be considered too.
Cost: Cost does not mean the expense of buying a particular medicine alone. It ought to also cover the expense of management of a complication that will arise from utilizing another drug. Example: Inside a person who insists on taking alcohol but must be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the consequences of alcohol, whereas another group of anti-depressants (including tricyclics) could cause a brand new condition in such patients, which may require a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. When there is a selection between a shot and oral administration, aforementioned is preferred when the efficacy of the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to choose simplicity of treatment.
To read more about medication go to our internet page: click for info
Be First to Comment