SINCE The second world war, medical science has progressed to some stage where competitive medications are available to treat exactly the same ailment in numerous people. This isn’t just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall go through the various factors that decide the selection of a particular drug.
Safety: These sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even though it’s got certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals answer make a different chemical, that have an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of each other, have certain effects using one or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This makes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same influence on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the prescription medication is more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability need to be looked at. Efficacy: A medication is not equally great at all patients. As an example, some patients with depression or anxiety disorders experience respite from escitalopram, but there are lots of who don’t, who therefore need to be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is a crucial step to be considered too.
Cost: Cost does not always mean the expense of purchase of a specific medicine alone. It must also cover the expense of treatments for a complication that may arise while using some other drug. Example: In the individual who insists on taking alcohol nevertheless should be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (such as tricyclics) can cause a fresh problem in such patients, which could demand a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. When there is an alternative between an injection and oral administration, the latter is preferred when the efficacy of the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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