Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Because of this, SARMs result in anabolic cellular activity while avoiding many of the unwanted effects of available given. SARMs happen to be studied in the treatment of breast cancers and cachexia and also have recently been utilized as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
To present the background, mechanisms, current and potential clinical applications, as well as risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and muscle tissue. Both research and scientific studies were included.
Main Outcome Measure
To finish a review of peer-reviewed literature.
Results
Although there are still no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Investigation has centered on the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability which has a paucity of drug interactions. Early scientific studies have demonstrated potential uses of SARMs from the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good results.
Conclusion
SARMs have numerous possible clinical applications, with promise to the safe used in the treatment of cachexia, BPH, hypogonadism, breast cancer, and cancer of the prostate.
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