Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Consequently, SARMs bring about anabolic cellular activity while avoiding lots of the negative effects of available steroids. SARMs have already been studied in the management of cancer of the breast and cachexia and possess recently been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
Presenting the background, mechanisms, current and potential clinical applications, in addition to risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean body mass. Both research and studies were included.
Main Outcome Measure
To finish an assessment of peer-reviewed literature.
Results
However, there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Investigation has focused on the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability using a paucity of drug interactions. Early clinical studies have demonstrated potential ways to use SARMs within the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good success.
Conclusion
SARMs have numerous possible clinical applications, with promise to the safe use in the treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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