SINCE World war 2, medical science has progressed to a stage where competitive medications are around for treat exactly the same ailment in several people. This isn’t just about brands (the trade issue) but generic drugs (the scientific issue). With this report, we shall look at the various factors that decide the selection of a certain drug.
Safety: These sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even when it’s got certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the potential side-effect of addiction.
* Long-term safety: medication could possibly be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals reply to create a different chemical, that have an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This causes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same impact on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both drugs are more serious.
Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to certain drugs in a few people. Short-term and long-term tolerability should be considered. Efficacy: A medication is just not equally great at all patients. By way of example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several who don’t, who therefore should be prescribed an alternative anti-depressant. The pace of start of therapeutic action is a key to be regarded as too.
Cost: Cost does not necessarily mean the price of acquisition of a specific medicine alone. It will also cover the price of treatment of a complication which could arise from utilizing an alternative drug. Example: Inside a individual who insists on taking alcohol and yet has to be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (such as tricyclics) may cause a fresh symptom in such patients, which would demand a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The easiest mode of administration is preferred. When there is a selection between a shot and oral administration, the latter is preferred if the efficacy of both modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
More details about medication see the best resource: click here
Be First to Comment