SINCE The second world war, medical science has progressed into a stage where competitive medications are around to treat the identical ailment in numerous people. This is simply not almost brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall consider the various factors that decide picking a a specific drug.
Safety: The following sub-criteria have to be considered underneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even if they have certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the potential side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals reply to create a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually make the same relation to the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the prescription medication is more serious.
Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability need to be looked at. Efficacy: A medication isn’t equally great at all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are numerous that don’t, who therefore need to be prescribed some other anti-depressant. The pace of onset of therapeutic action is an important the answer to be considered too.
Cost: Cost does not mean the cost of acquiring a particular medicine alone. It will also cover the cost of treatment of a complication that may arise while using some other drug. Example: In a person who insists on taking alcohol nevertheless should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (like tricyclics) could cause a new overuse injury in such patients, which could need a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you have an option between an injection and oral administration, aforementioned is preferred in the event the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to choose simple treatment.
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